Member Profile Member Name Slayton, William B Degree(s) M.D. Academic Title/Position Assistant Professor College MEDICINE Department PEDIATRICS PO Box 100296 Business Mailing Address 1600 SW Archer Rd. Gainesville, FL 32610 Office Building & Room Number R4-252 Office Phone 352-392-0214 Lab Building & Room Number R4-277 Lab Phone 352-392-0214 Fax 352-392-8725 Business E-Mail Address slaytwb@peds.ufl.edu Research Programs Clinical and Translational Research Programs Experimental Therapeutics Research Interests Research Interests Group DNA Damage & Repair; Hematologic Malignancies/Blood & Marrow Transplant; Pediatric Oncology; Vascular Targeting   Brief summary of research interests Dr. Slayton's research includes a laboratory based component studying bone marrow vasculature as it affects normal megakaryocyte development and leukemogenesis. He is also involved in international clinical trials for children with acute lymphoblastic leukemia (ALL) conducted by the Children's Oncology Group (COG). He participated in the Infant Leukemia trial where he was a member of the transplant and basic science subcommittee. He also was a member of the Very High Risk Leukemia Committee which tested the role of imatinib in the treatment of Philadelphia Chromosome positive ALL. He has developed and is chairing the successor trial for Ph+ acute lymphoblastic trial using a second generation targeted tyrosine kinase inhibition (dasatinib) in combination with an intensive chemotherapy backbone. He is looking at ways of combining targeted therapies for Ph+ leukemia to reduce toxicity.